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The Use of Forelimb Asymmetry Functional Tests to Determine Motor Recovery With Various Drug Treatments Following Endothelin-Induced Stroke

Leach, Kelly Rebecca
http://rave.ohiolink.edu/etdc/view?acc_num=wright1344607995

Abstract Details

2012, Master of Science (MS), Wright State University, Physiology and Neuroscience.
Our laboratory has found increased functional recovery post-stroke with Long Evans rats that received a combination of fluoxetine, simvastatin, and vitamin C. The objectives of this study were to test that treatment and other drug combinations on Sprague Dawley rats, to determine whether Forelimb Asymmetry is a reliable behavioral measure for stroke studies, and to determine the most optimal surgical procedure on Sprague Dawley rats. There were more significant increases in functional recovery observed on the Forelimb Asymmetry than on Montoya Staircase behavioral tests, but there were no significant differences between treatment groups and control. The largest number of rats that had at least a 20% deficit was in the group that underwent stroke induction through injecting 1.5ul endothelin into the strereotactic sites AP (0), ML (-2.5), DV (2.0) and AP (1.5), ML (-2.5), DV (2.0) from bregma, which should be utilized in future stroke studies with Sprague Dawley rats.
Adrian Corbett, PhD (Advisor)
Kathrin Engisch, PhD (Committee Member)
Robert Putnam, PhD (Committee Member)
58 p.
Neurosciences
forelimb asymmetry; endothelin; ischemic stroke; fluoxetine; statins; SSRIs; vitamin C

Recommended Citations

Citations

  • Leach, K. R. (2012). The Use of Forelimb Asymmetry Functional Tests to Determine Motor Recovery With Various Drug Treatments Following Endothelin-Induced Stroke [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1344607995

    APA Style (7th edition)

  • Leach, Kelly. The Use of Forelimb Asymmetry Functional Tests to Determine Motor Recovery With Various Drug Treatments Following Endothelin-Induced Stroke. 2012. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1344607995.

    MLA Style (8th edition)

  • Leach, Kelly. "The Use of Forelimb Asymmetry Functional Tests to Determine Motor Recovery With Various Drug Treatments Following Endothelin-Induced Stroke." Master's thesis, Wright State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1344607995

    Chicago Manual of Style (17th edition)

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© 2012, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.
Release 3.2.12