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Thesis-Dan Yi.pdf (2.78 MB)

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Tolfenamic Acid Induces Cell Apoptosis and Inhibits Collagen Accumulation in Keloid Fibroblasts

Yi, Dan
http://rave.ohiolink.edu/etdc/view?acc_num=wright1375783902

Abstract Details

2013, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
Keloid scar is a fibroproliferative disorder which results from the accumulation of collagen through the activation of TGF-B/Smad signaling. Tolfenamic acid (TA) has been found to inhibit collagen synthesis in animal and induce cancer cell apoptosis. In this study, we investigated the effect of DMSO on cell apoptosis, TA on collagen deposition, and TA on collagen type I and smad2 protein expression in human normal fibroblasts (NFs) and human keloid fibroblasts (KFs). In the dose- and exposure time- response assays, we found that 1% DMSO for 48h treatment did not obviously induce NF and KF apoptosis and that 0.55x10-3 M TA for 48h treatment remarkably decreased NF and KF proliferation. Under these experimental conditions, we further found that TA selectively induced cell apoptosis, strikingly decreased collagen production, and effectively inhibited collagen type I expression in KFs. Our data suggested that TA induces cell apoptosis and inhibits collagen accumulation in KFs.
Richard Simman, M.D. (Committee Chair)
Yanfang Chen, M.D., Ph.D. (Committee Co-Chair)
David Cool, Ph.D. (Committee Member)
73 p.
Pharmacology
keloid scar, collagen, tolfenamic acid

Recommended Citations

Citations

  • Yi, D. (2013). Tolfenamic Acid Induces Cell Apoptosis and Inhibits Collagen Accumulation in Keloid Fibroblasts [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1375783902

    APA Style (7th edition)

  • Yi, Dan. Tolfenamic Acid Induces Cell Apoptosis and Inhibits Collagen Accumulation in Keloid Fibroblasts. 2013. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1375783902.

    MLA Style (8th edition)

  • Yi, Dan. "Tolfenamic Acid Induces Cell Apoptosis and Inhibits Collagen Accumulation in Keloid Fibroblasts." Master's thesis, Wright State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1375783902

    Chicago Manual of Style (17th edition)

wright1375783902
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© 2013, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.