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Cox Thesis 01-13-2015 Final Copy.pdf (1.15 MB)

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Synthesis and Biological Activity of Indolinones

Cox, Kaleb Woodrow
http://rave.ohiolink.edu/etdc/view?acc_num=wright1421165680

Abstract Details

2014, Master of Science (MS), Wright State University, Chemistry.
Indolinones of the type known as Arylidene oxindoles have been demonstrated to possess a broad range of activity ranging from proten kinase inhibtors, cell-death inhibitors and tau protein binding agents. Small libraries of such molecules were designed and synthesized herein in modifications involving variously substituted halogen derivatives, N-alkylation of the indolinone nitrogen, and finally a new class of molecules, namely arylidene oxindoles possessing extended conjugation. The biological activities of such molecules were examined and the results disclosed herein.
Daniel Ketcha , Ph.D. (Advisor)
Eric Fossum, Ph.D. (Committee Member)
Kenneth Turnbull, Ph.D. (Committee Member)
David Grossie, Ph.D. (Other)
92 p.
Chemistry
chemistry

Recommended Citations

Citations

  • Cox, K. W. (2014). Synthesis and Biological Activity of Indolinones [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1421165680

    APA Style (7th edition)

  • Cox, Kaleb. Synthesis and Biological Activity of Indolinones. 2014. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1421165680.

    MLA Style (8th edition)

  • Cox, Kaleb. "Synthesis and Biological Activity of Indolinones." Master's thesis, Wright State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1421165680

    Chicago Manual of Style (17th edition)

wright1421165680
389
© 2014, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.