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Regulation of Motoneuron Firing Properties: Intrinsic and Circuit-Based Mechanisms

Deardorff, Adam S.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1432851525

Abstract Details

2015, Doctor of Philosophy (PhD), Wright State University, Biomedical Sciences PhD.
Body and limb movements are controlled by regulating the activity of motor pools and their constituent motoneurons. An extensive complement of tightly regulated ion channels and second messenger systems determine active motoneuron spiking behavior, while segmental propriospinal circuits ensure the faithful execution of motor commands by providing real time sensory feedback to motoneurons and other somatosensory centers. However, current mechanistic understanding is incomplete for critical factor regulating motoneuron firing properties. Fundamental gaps in knowledge exist regarding (a) the spatial distribution and organization of specific ion channels in motoneurons, (b) the contribution of specific channels to motoneuron intrinsic properties, (c) the rules governing interactions between segmental interneuronal populations and motoneurons, and (d) patterns of motoneuron synaptic connectivity across flexor and extensor motor pools. Studies undertaken in this dissertation are aimed at filling several of these gaps in our current understanding of motoneuron behavior. Multiple factors that affect a-MN excitability and firing are examined, including select ion channels, intrinsic membrane properties, and synaptic inputs. In addition, one series of studies was undertaken to advance understanding how some of these factors respond to peripheral nerve injury.
Robert Fyffe, Ph.D. (Advisor)
Timothy Cope, Ph.D. (Advisor)
Courtney Sulentic, Ph.D. (Committee Member)
Kathrin Engisch, Ph.D. (Committee Member)
F. Javier Alvarez-Leefmans, M.D., Ph.D. (Committee Member)
271 p.
Neurosciences
neurosciences

Recommended Citations

Citations

  • Deardorff, A. S. (2015). Regulation of Motoneuron Firing Properties: Intrinsic and Circuit-Based Mechanisms [Doctoral dissertation, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1432851525

    APA Style (7th edition)

  • Deardorff, Adam. Regulation of Motoneuron Firing Properties: Intrinsic and Circuit-Based Mechanisms. 2015. Wright State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1432851525.

    MLA Style (8th edition)

  • Deardorff, Adam. "Regulation of Motoneuron Firing Properties: Intrinsic and Circuit-Based Mechanisms." Doctoral dissertation, Wright State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1432851525

    Chicago Manual of Style (17th edition)

wright1432851525
471
© 2015, some rights reserved.Creative Commons License Regulation of Motoneuron Firing Properties: Intrinsic and Circuit-Based Mechanisms by Adam S. Deardorff is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.