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Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation

Dharmadhikari, Sayali Ravindra
http://orcid.org/0000-0002-3367-4461
http://rave.ohiolink.edu/etdc/view?acc_num=wright1470835878

Abstract Details

2016, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
In this study, we hypothesize that a pharmacological drug treatment comprised of Fluoxetine, Simvastatin and Ascorbic acid together with physical rehabilitation would reduce infarct sizes. Over the period of 60 days after stroke-induction, 13 of the 23 rats were administered the drugs beginning 20-26 hours after stroke-induction and the rest were assigned to the control group. Physical rehabilitation exercises were initiated from poststroke day 8 and continued for 23 alternate days. The rats were tested for functional recovery using Montoya staircase apparatus and were euthanized after post-stroke day 60. The brains sections were analyzed using Nissl stain for infarct volume analysis. Due to the excess amount physical rehabilitation exercise in comparison to the previous studies conducted in our laboratory, the rats suffered large amount of stress. Stress antagonizing neurogenesis is believed to be the reason for lack of motor functional recovery and lack of any reduction in infarct sizes.
Adrian Corbett, Ph.D. (Advisor)
Yanfeng Chen, M.D., Ph.D. (Committee Member)
Ji Chen Bihl, M.D., Ph.D. (Committee Member)
148 p.
Neurobiology; Neurology; Neurosciences; Pharmacology; Rehabilitation
Stroke; fluoxetine; simvastatin; ascorbic acid; rat; rehabilitation; infarct volume; Montoya Staircase; Forelimb Asymmetry;

Recommended Citations

Citations

  • Dharmadhikari, S. R. (2016). Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1470835878

    APA Style (7th edition)

  • Dharmadhikari, Sayali. Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation . 2016. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1470835878.

    MLA Style (8th edition)

  • Dharmadhikari, Sayali. "Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation ." Master's thesis, Wright State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1470835878

    Chicago Manual of Style (17th edition)

wright1470835878
547
© 2016, some rights reserved.Creative Commons License Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation by Sayali Ravindra Dharmadhikari is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.
Release 3.2.12