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Effects of Myrrh on HSV-1 Using Plaque Assay

Alamri, Badrieah Mohammad
http://rave.ohiolink.edu/etdc/view?acc_num=wright1481628828816542

Abstract Details

2017, Master of Science (MS), Wright State University, Microbiology and Immunology.
Herpes simplex virus type 1 (HSV-1) is a highly infective human pathogen which infects a wide range of population in North America and worldwide. HSV-1 infection has two phases, lytic and latent. Recurrence of HSV-1 is a major challenge to clinicians to control the infection especially in immune depleted individuals. Acyclovir (ACV) is an antiviral drug used to treat HSV-1 infection. Low solubility of ACV in water, mutation of viral thymidine kinase, and mutation of viral DNA polymerase are major problems that cause usage limitations of ACV. Myrrh has been used as an analgesic and anti-inflammatory natural product in middle eastern countries for centuries. Recently Myrrh has shown a promising therapeutic action against fungal and parasitic infections. In the current study, low concentrations of Myrrh treatment increased cell survival of HSV-1 infected Vero cells. Prolonged exposure to Myrrh was found to be toxic to viable cells. Myrrh treatment of HSV-1 infected Vero cells was compared with ACV treatment of HSV-1 infected Vero cell. Myrrh treatment increased cell survival of infected Vero cells, similar to the effect of ACV treatment. These results provide evidence that Myrrh exerts antiviral effects against herpes virus infection.
Nancy Bigley, Ph.D. (Committee Chair)
Barbara Hull, Ph.D. (Committee Member)
Dawn Wooley, Ph.D. (Committee Member)
56 p.
Immunology
Myrrh; HSV-1; Vero cells

Recommended Citations

Citations

  • Alamri, B. M. (2017). Effects of Myrrh on HSV-1 Using Plaque Assay [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1481628828816542

    APA Style (7th edition)

  • Alamri, Badrieah. Effects of Myrrh on HSV-1 Using Plaque Assay. 2017. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1481628828816542.

    MLA Style (8th edition)

  • Alamri, Badrieah. "Effects of Myrrh on HSV-1 Using Plaque Assay." Master's thesis, Wright State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1481628828816542

    Chicago Manual of Style (17th edition)

wright1481628828816542
393
© 2017, some rights reserved.Creative Commons License Effects of Myrrh on HSV-1 Using Plaque Assay by Badrieah Mohammad Alamri is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.