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Mechanical Stresses on Nasal Mucosa Using Nose-On-Chip Model

Brooks, Zachary Edward
http://orcid.org/0000-0003-0455-2841
http://rave.ohiolink.edu/etdc/view?acc_num=wright1578492176817977

Abstract Details

2019, Master of Science in Biomedical Engineering (MSBME), Wright State University, Biomedical Engineering.
The objective of this research was to design and fabricate a nose-on-chip device and bi-directional airflow system that models flow within the nasal cavity to investigate how airflow induced mechanical stresses impact nasal secretion rates and cytoskeletal remodeling. This research hypothesizes that the airflow induced shear stresses on the nasal mucosa will influence mucus production and the cytoskeleton of the cells. The RPMI 2650 cell line was used to model the nasal mucosa. The system was used to replicate the wall shear stresses (WSS) and wall shear forces (WSF) present in the anterior region of the nose. The WSS and WSF within the device were validated using calculations and CFD simulation. It was found that the WSS and WSF increase mucus secretion with higher durations of exposure and influence cytoskeletal integrity. A prediction equation was derived to predict the mucus production of RPMI 2650 cells modeling the anterior region.
Tarun Goswami, D.Sc. (Advisor)
Ulas Sunar, Ph.D. (Committee Member)
Jaime Ramirez-Vick, Ph.D. (Committee Member)
Angela Dixon, Ph.D. (Committee Member)
Saber Hussain, Ph.D. (Committee Member)
154 p.
Biomedical Engineering; Engineering
Microfluidic; Nose-on-Chip; Wall Shear Stress; Wall Shear Force; RPMI 2650; Mucus Production; Nasal Model

Recommended Citations

Citations

  • Brooks, Z. E. (2019). Mechanical Stresses on Nasal Mucosa Using Nose-On-Chip Model [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578492176817977

    APA Style (7th edition)

  • Brooks, Zachary. Mechanical Stresses on Nasal Mucosa Using Nose-On-Chip Model. 2019. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1578492176817977.

    MLA Style (8th edition)

  • Brooks, Zachary. "Mechanical Stresses on Nasal Mucosa Using Nose-On-Chip Model." Master's thesis, Wright State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578492176817977

    Chicago Manual of Style (17th edition)

wright1578492176817977
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© 2019, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.