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YAKSHKUMAR RATHOD THESIS.pdf (1.32 MB)
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Abstract Header
The feeding pattern of C57BL/6J mice
Author Info
Rathod, Yakshkumar Dilipbhai
ORCID® Identifier
http://orcid.org/0000-0002-3488-5893
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=wright15988948196526
Abstract Details
Year and Degree
2020, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
Abstract
The feeding pattern and control of energy intake in social mice are poorly understood. Here, we determined and quantify the normal nocturnal feeding pattern of group-housed male and female mice of the C57BL/6J genetic background fed a chow diet. Mice at 10 and 20weeks of age showed the expected age-dependent increase in lean and fat mass being them more pronounced in males. Under ad libitum conditions, male and female mice ate comparable amounts of food per unit of body weight irrespective of gender. The analysis of the feeding microstructure revealed that energy intake in females is the result of significantly increased nocturnal meal size, but decreased meal frequency, relative to males suggesting that food has reduced satiation value to social females than to males. The intermeal interval was significantly increased in female mice relative to males, but only at 10weeks of age, indicating increased satiety value of food in younger females. The increased meal size observed in females was accompanied by increased meal duration, which translated to significant reduction in the feeding rate of younger females but not in older mice fed ad libitum. In response to prolonged fasting, male and female mice lost comparable body mass, but females recovered it faster than males in spite of eating equivalent amount of food as males. Further, younger but not older female mice fasted 16hs robustly increased their meal size during the first hours of re-feeding whereas males did not, suggesting reduced inhibition of satiation in fasted young female mice relative to males. Both, fasted males and female mice significantly reduced their intermeal interval during the first hours of re-feeding to similar extents independently of their age suggesting that fasting inhibits satiety in mice. Therefore, when taken together these results demonstrate that satiation and satiety signals governing energy intake in mice are sex- and age-dependent.
Committee
Mauricio Di Fulvio, Ph.D. (Advisor)
Khalid Elased, Pharm.D., Ph.D. (Committee Member)
J. Ashot Kozak, Ph.D. (Committee Member)
Pages
85 p.
Subject Headings
Endocrinology
;
Pharmacology
Keywords
Satiation
;
Satiety
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Citations
Rathod, Y. D. (2020).
The feeding pattern of C57BL/6J mice
[Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright15988948196526
APA Style (7th edition)
Rathod, Yakshkumar.
The feeding pattern of C57BL/6J mice.
2020. Wright State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=wright15988948196526.
MLA Style (8th edition)
Rathod, Yakshkumar. "The feeding pattern of C57BL/6J mice." Master's thesis, Wright State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright15988948196526
Chicago Manual of Style (17th edition)
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Document number:
wright15988948196526
Download Count:
137
Copyright Info
© 2020, some rights reserved.
The feeding pattern of C57BL/6J mice by Yakshkumar Dilipbhai Rathod is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.