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Assessment of In Vivo Muscle Force in the R6/2 Mouse Model of Huntington's Disease Using Newly Designed Force Rig

Burke, Steven Russell Alan
http://orcid.org/0000-0001-9167-3806
http://rave.ohiolink.edu/etdc/view?acc_num=wright1610360658382723

Abstract Details

2020, Master of Science (MS), Wright State University, Biological Sciences.
In this thesis, we develop a system to study in vivo muscle function in a mouse model of Huntington’s disease that allows for the recording of muscle force by stimulating the motor nerves or the muscles directly after a nerve block. This allows us to distinguish between defects in the nerve, such as problems with vesicle release, and primary muscle defects, such as altered intracellular calcium homeostasis. We hypothesize that there are primary defects in R6/2 skeletal muscle that are separate from neurodegeneration or defects in the CNS. In this case, we should see defects in muscle force generation during nerve stimulation and direct muscle stimulation. If our hypothesis is shown to be correct, this work would highlight new targets to study for the treatment of HD. Peripheral treatments of skeletal muscle are a promising area for the treatment of HD as motor defects are debilitating for patients.
Andrew Voss, Ph.D. (Advisor)
Mark Rich, M.D., Ph.D. (Committee Member)
Lynn Hartzler, Ph.D. (Committee Member)
82 p.
Biology; Biomedical Research
huntingtons; disease; mouse; model; force; in vivo; skeletal; muscle; nerve; r62; mice; frequency;

Recommended Citations

Citations

  • Burke, S. R. A. (2020). Assessment of In Vivo Muscle Force in the R6/2 Mouse Model of Huntington's Disease Using Newly Designed Force Rig [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610360658382723

    APA Style (7th edition)

  • Burke, Steven. Assessment of In Vivo Muscle Force in the R6/2 Mouse Model of Huntington's Disease Using Newly Designed Force Rig. 2020. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1610360658382723.

    MLA Style (8th edition)

  • Burke, Steven. "Assessment of In Vivo Muscle Force in the R6/2 Mouse Model of Huntington's Disease Using Newly Designed Force Rig." Master's thesis, Wright State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610360658382723

    Chicago Manual of Style (17th edition)

wright1610360658382723
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This open access ETD is published by Wright State University and OhioLINK.