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Using fMRI BOLD Imaging to Motion-Correct Associated, Simultaneously Imaged PET Data

Williamitis, Joseph M.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1620585748146734

Abstract Details

2021, Master of Science (MS), Wright State University, Anatomy.
Because magnetic resonance (MR) and positron emission tomography (PET) scanning sessions last long durations, motion blur during scanning constitutes a problem for clinical interpretation. To counteract this, motion-correction algorithms have been developed to reduce smearing between scan slices of MRI, but these algorithms are not commonplace for PET. This feasibility study determined if applying MRI motion-correction algorithms to simultaneously acquired PET data improved PET signal clarity in specific brain regions. Seven subjects received increasing levels of PET tracers while undergoing two separate simultaneous PET/MRI scans. We modified existing fMRI algorithms to apply them to the accompanying PET data. We hypothesized gray matter activity was low due to motion-blurring, and correction would result in increased signal intensity. We evaluated this and other internal brain regions using a Wilcoxon Signed-Rank statistical test. We failed to reject the null hypothesis as no regions showed significant differences between the motion-corrected and raw data.
Robert M. Lober, M.D., Ph.D. (Committee Chair)
Matthew S. Sherwood, Ph.D. (Committee Co-Chair)
David R. Ladle, Ph.D. (Committee Member)
54 p.
Anatomy and Physiology; Biomedical Engineering; Biomedical Research; Medical Imaging; Neurobiology; Neurology; Neurosciences
fMRI; BOLD; PET; Scanning; PET MR

Recommended Citations

Citations

  • Williamitis, J. M. (2021). Using fMRI BOLD Imaging to Motion-Correct Associated, Simultaneously Imaged PET Data [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1620585748146734

    APA Style (7th edition)

  • Williamitis, Joseph. Using fMRI BOLD Imaging to Motion-Correct Associated, Simultaneously Imaged PET Data. 2021. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1620585748146734.

    MLA Style (8th edition)

  • Williamitis, Joseph. "Using fMRI BOLD Imaging to Motion-Correct Associated, Simultaneously Imaged PET Data." Master's thesis, Wright State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1620585748146734

    Chicago Manual of Style (17th edition)

wright1620585748146734
839
© 2021, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.
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