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Valerie Thesis draft 5.0.pdf (1.11 MB)

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The Effect of Endogenous Ligands of the Aryl Hydrocarbon Receptor on Antibody Expression in a Human B-Cell Model

Benedict, Valerie
http://rave.ohiolink.edu/etdc/view?acc_num=wright1622126480271197

Abstract Details

2021, Master of Science (MS), Wright State University, Anatomy.
Small changes in antibody expression have broad impacts on human health and disease. An environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces profound immune suppression in animal models in an aryl hydrocarbon receptor (AhR)-mediated fashion. In a human Burkitt's lymphoma cell line (CL-01), TCDD inhibited IgG secretion and differentially impacted Ig heavy chain expression. In addition to TCDD, the AhR has several endogenous, dietary, and bacterial ligands such as 6-formylindolo[3,2-b]carbazole (FICZ) and indole, which are present within the human body at varied concentrations (0.30 mM- 6.64 mM). Both FICZ (100 nM) and indole (100 µM) significantly reduced IgG secretion. Overall antibody secretion is less sensitive to endogenous ligands of the AhR than TCDD, which inhibits IgG secretion in the nM concentration range. However, antibody secretion is inhibited by FICZ, suggesting a biological role of the AhR in antibody expression.
Courtney Sulentic, Ph.D. (Advisor)
Nancy Bigley, Ph.D. (Committee Member)
Thomas Brown, Ph.D. (Committee Member)
Eric Bennett, Ph.D. (Other)
89 p.
Biology
AhR; FICZ; Indole; TCDD; B-Cell; Endogenous ligands of AhR

Recommended Citations

Citations

  • Benedict, V. (2021). The Effect of Endogenous Ligands of the Aryl Hydrocarbon Receptor on Antibody Expression in a Human B-Cell Model [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622126480271197

    APA Style (7th edition)

  • Benedict, Valerie. The Effect of Endogenous Ligands of the Aryl Hydrocarbon Receptor on Antibody Expression in a Human B-Cell Model. 2021. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1622126480271197.

    MLA Style (8th edition)

  • Benedict, Valerie. "The Effect of Endogenous Ligands of the Aryl Hydrocarbon Receptor on Antibody Expression in a Human B-Cell Model." Master's thesis, Wright State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622126480271197

    Chicago Manual of Style (17th edition)

wright1622126480271197
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© 2021, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.