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Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis

Curran, Maura A.
http://orcid.org/0000-0002-0981-3337
http://rave.ohiolink.edu/etdc/view?acc_num=wright1660313651933497

Abstract Details

2022, Master of Science (MS), Wright State University, Physiology and Neuroscience.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. To date, there are no significant disease-modifying treatments, and one limiting factor in treatment is the amount of time it takes for a patient to receive a diagnosis of ALS. This study examined multiple mouse models before symptom onset to help identify early changes in a reflex circuit of ALS mice. Dorsal root stimulation of the sacral spinal cord in multiple models ALS mouse models showed changes in the resulting ventral root compound action potential amplitude, latency, and ability to maintain synaptic depression. These data also suggest that a mouse model of TDP43 inclusions is fundamentally different in its network properties than that of SOD1 ALS mutant mice. While these data suggest changes in motor neuron excitability may play a contributing factor, there are likely other synaptic changes involved, but further work needs to be done to verify this.
Sherif M. Elbasiouny, Ph.D., P.E., P.Eng. (Advisor)
David Ladle, Ph.D. (Committee Member)
Mark Rich, M.D., Ph.D. (Committee Member)
48 p.
Neurosciences
Amyotrophic Lateral Sclerosis; SOD1; TDP43;

Recommended Citations

Citations

  • Curran, M. A. (2022). Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1660313651933497

    APA Style (7th edition)

  • Curran, Maura. Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis. 2022. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1660313651933497.

    MLA Style (8th edition)

  • Curran, Maura. "Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis." Master's thesis, Wright State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=wright1660313651933497

    Chicago Manual of Style (17th edition)

wright1660313651933497
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This open access ETD is published by Wright State University and OhioLINK.