Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


Final thesis-Harsimran.pdf (10.24 MB)

ETD Abstract Container

Abstract Header

Estimation of the amount of Active Pharmaceutical Ingredient in over-the-counter available aspirin formulations using titrimetry, UV-Visible spectrophotometry and Raman spectroscopy

Chahal, Harsimranjeet K.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1660386169486507

Abstract Details

2022, Master of Science (MS), Wright State University, Chemistry.
Counterfeit pharmaceuticals are a serious threat to public safety worldwide. Adverse health effects including resistance to treatment and death have resulted from the consumption of such medicines. Aspirin, which is a non-steroidal anti-inflammatory drug, has been counterfeited in the past due to its increasing demand. Rapid and easy analytical methods are needed to detect these counterfeit medicines and put a halt to the growing number of such incidents. In this study, quantitative estimation of active pharmaceutical ingredient (API) content in different over-the-counter available aspirin tablets was done using titrimetry and UV- Visible spectrophotometry. Qualitative analysis was done using Raman spectroscopy. The quantitative results showed that the amount of API calculated in different brands using both methods was close to the amount of the API listed on the label. Student’s t-test indicated that there were no statistical differences in the results calculated from both methods. Raman spectra indicated the presence of impurities in some brands. The study demonstrated that titrimetry, UV-Visible spectrophotometry and Raman spectroscopy can be used to detect the amount of API in pharmaceutical formulations.
Steven R. Higgins, Ph.D. (Advisor)
David A. Dolson, Ph.D. (Committee Member)
Rachel S. Aga, Ph.D. (Committee Member)
Ioana E. Pavel, Ph.D. (Committee Member)
93 p.
Chemistry
Counterfeit pharmaceuticals; aspirin

Recommended Citations

Citations

  • Chahal, H. K. (2022). Estimation of the amount of Active Pharmaceutical Ingredient in over-the-counter available aspirin formulations using titrimetry, UV-Visible spectrophotometry and Raman spectroscopy [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1660386169486507

    APA Style (7th edition)

  • Chahal, Harsimranjeet. Estimation of the amount of Active Pharmaceutical Ingredient in over-the-counter available aspirin formulations using titrimetry, UV-Visible spectrophotometry and Raman spectroscopy. 2022. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1660386169486507.

    MLA Style (8th edition)

  • Chahal, Harsimranjeet. "Estimation of the amount of Active Pharmaceutical Ingredient in over-the-counter available aspirin formulations using titrimetry, UV-Visible spectrophotometry and Raman spectroscopy." Master's thesis, Wright State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=wright1660386169486507

    Chicago Manual of Style (17th edition)

wright1660386169486507
312
© 2022, some rights reserved.Creative Commons License Estimation of the amount of Active Pharmaceutical Ingredient in over-the-counter available aspirin formulations using titrimetry, UV-Visible spectrophotometry and Raman spectroscopy by Harsimranjeet K. Chahal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.