Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ysu1288363170.pdf (667.5 KB)

ETD Abstract Container

Abstract Header

Purification and Characterization of Type 5 Staphylococcus aureus

Rudnicki, Thomas
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170

Abstract Details

2010, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
Staphylococcus aureus (S. aureus) infections are notoriously difficult to treat due to antibiotic resistance and virulence. One virulence factor employed by S. aureus is a protective polysaccharide coating called a capsule. This structural component plays a significant role in immune response evasion. Drugs that target bacterial capsule circumvent the mechanisms utilized by traditional antibiotics and create a novel way to treat S. aureus infections. A systematic purification and characterization of the capsule can further drug development by elucidating the immunological interaction of this element. Purification of the capsule was achieved by implementing ion-exchange, size exclusion chromatography, and enzymatic digestion. The purified sample was then characterized by NMR spectroscopy.
Diana Fagan, PhD (Advisor)
Peter Norris, PhD (Committee Member)
Nina Stourman, PhD (Committee Member)
71 p.
Biology; Chemistry
Antibiotic resistant Staphylococcus aureus; Capsular polysaccharide; Glycobiology

Recommended Citations

Citations

  • Rudnicki, T. (2010). Purification and Characterization of Type 5 Staphylococcus aureus [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170

    APA Style (7th edition)

  • Rudnicki, Thomas. Purification and Characterization of Type 5 Staphylococcus aureus. 2010. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170.

    MLA Style (8th edition)

  • Rudnicki, Thomas. "Purification and Characterization of Type 5 Staphylococcus aureus." Master's thesis, Youngstown State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170

    Chicago Manual of Style (17th edition)

ysu1288363170
575
© 2010, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.