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Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods

Clark, Abigail R
http://orcid.org/0000-0003-1340-156X
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954

Abstract Details

2022, Master of Science (MS), Bowling Green State University, Forensic Science.
Recent legislative changes in Ohio have led to crime laboratories making procedural changes away from qualitative analysis toward quantitative analysis of cannabinoid products. Several laboratories have developed methods for quantifying cannabinoids, but difficulties in sample preparation have impacted these methods. There are a multitude of cannabinoid products that exist, and food-based products predominantly consist of complex matrices. These matrices hinder the concentration of extracted cannabinoids, leading to an insufficient representation of those present. Four different methods of extraction expected to provide sufficient extraction of cannabidiol (CBD) were compared, specifically a QuEChERS method, an acetonitrile soak, a multi-solvent extraction utilized by the Virginia Department of Forensic Science (DFS), and a solvent comprised of methanol, formic acid, and water. These methods were tested on three flavors of “WYLD” CBD gummies: blackberry, huckleberry, and raspberry, as well as a control group using Annie’s Bunny Gummies containing no CBD. Based on percent recovery analysis, the manufacturer’s reported concentration of CBD contained within the gummies was significantly higher than the extracted values. However, no significant differences were found between the three gummy flavors, nor the three extraction methods that yielded results. There was statistically significant difference observed when comparing the control groups to the actual CBD gummies. Further research is required to determine reproducibility of results and optimization of the methods proposed.
Travis Worst, PhD. (Advisor)
Crystal Oechsle, PhD. (Committee Member)
Tanieka Motley, PhD. (Committee Member)
42 p.
Analytical Chemistry; Chemistry; Pharmacology
Cannabinoids; Cannabidiol; Extraction; Quantification; Solvent-Based; QuEChERS; LC/MS

Recommended Citations

Citations

  • Clark, A. R. (2022). Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954

    APA Style (7th edition)

  • Clark, Abigail. Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods. 2022. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954.

    MLA Style (8th edition)

  • Clark, Abigail. "Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods." Master's thesis, Bowling Green State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954

    Chicago Manual of Style (17th edition)

bgsu1648754057865954
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© 2022, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.